Leevarin 50 Injection [Calcium Leucovorin (10mg/ml)]

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

'- Alcohol : CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Leevarin 50 Injection. Please consult your doctor.

- Pregnancy : CONSULT YOUR DOCTOR

Leevarin 50 Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

- Breast feeding : CONSULT YOUR DOCTOR

Information regarding the use of Leevarin 50 Injection during breastfeeding is not available. Please consult your doctor.

- Driving : SAFE

Leevarin 50 Injection does not usually affect your ability to drive.

- Kidney : CONSULT YOUR DOCTOR

There is limited information available on the use of Leevarin 50 Injection in patients with kidney disease. Please consult your doctor.

- Liver : CONSULT YOUR DOCTOR

There is limited information available on the use of Leevarin 50 Injection in patients with liver disease. Please consult your doctor.

If you miss a dose of Leevarin 50 Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

vial of 5 ml Injection

Chemical Class :: Glutamic acid Derivatives
Habit Forming :: No
Therapeutic Class :: BLOOD RELATED
Action Class :: Cytoprotective agents- methotrexate

Prevention of Harmful effects of methotrexate

Store below 25?C

Q. What is Leevarin 50 Injection used for?::: Leevarin 50 Injection is used to prevent harmful effects of methotrexate (cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Leevarin 50 Injection is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. It is also used for the treatment of megaloblastic anemia due to folic acid deficiency and when oral therapy is not feasible.| Q. What is megaloblastic anemia?::: Anemia is a blood disorder in which the number of red blood cells (RBCs) that carry oxygen is lower than usual. As a result, your tissues and organs don???t get enough oxygen. Megaloblastic anemia is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells. Usually, megaloblastic anemia is due to vitamin B12 or folic acid deficiency. How long does it take for Leevarin 50 Injection to work?| Q. How long does it take for Leevarin 50 Injection to work?::: Leevarin 50 Injection starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.| Q. What are some of the laboratory tests conducted before or during the treatment with Leevarin 50 Injection?::: Your doctor will prescribe blood tests to check your levels of serum methotrexate concentration (in case of methotrexate chemotherapy or overdose) to determine the optimal dose and duration of treatment with Leevarin 50 Injection. You will also be prescribed a complete blood count to monitor the number of red blood cells (in case of megaloblastic anemia). Along with this, your calcium levels will also be monitored in order to prevent hypercalcemia (excess calcium) since Leevarin 50 Injection contains calcium.| Q. What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Leevarin 50 Injection?::: Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.